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Patterns of gene expression in muscle and fat in tumor-bearing rats: Effects of CRF2R agonist on cachexia

✍ Scribed by Josep M. Argilés; Cibely Cristine Fontes-Oliveira; Gemma Fuster; Elisabet Ametller; Maite Figueras; Mireia Olivan; Francisco J. Lopez-Soriano; Xiaoyan Qu; Jeffrey Demuth; Paula Stevens; Alex Varbanov; Feng Wang; Robert J. Isfort; Sílvia Busquets

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
284 KB
Volume
42
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

The hypothesis we tested was that administering corticotropin‐releasing factor receptor agonists preserves muscle mass during cancer that is related to changes in tissue gene expression. cDNA microarrays were used to compare mRNAs from muscle and adipose tissues of non‐treated and agonist‐treated tumor‐bearing rats. In muscle of non–tumor‐bearing agonist‐treated animals we observed decreased expression of genes associated with fatty acid uptake and esterification. In tumor‐bearing animals, CRF2R agonist administration produced decreased mRNA content of the atrogene lipin‐1. In white adipose tissue, agonist treatment of non–tumor‐bearing animals induced genes typically related to muscle structure and function. The fact that this treatment decreased expression of atrogenes could have clinical application. In addition, agonist treatment changed the gene pattern of adipose tissue to render it similar to that of skeletal muscle; thus, treatment with this agonist alters the gene pattern to what could be called “muscularization of white adipose tissue.” Muscle Nerve 42:936–949, 2010

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