Patterns of care in elderly glioblastoma patients

✍ Scribed by Fabio M. Iwamoto; Anne S. Reiner; Katherine S. Panageas; Elena B. Elkin; Lauren E. Abrey

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 315 KB
• Volume: 64
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.21521

✦ Synopsis

Abstract

Objective

To evaluate the patterns of care in elderly glioblastoma (GBM) patients from a large population‐based registry.

Methods

We identified a cohort of GBM patients 65 years or older from Surveillance, Epidemiology, and End Results cancer registry data linked with Medicare claims between 1994 and 2002. We assessed the impact of demographic characteristics and comorbidities on the probability of undergoing surgical resection, radiotherapy (RT), and chemotherapy within 3 months of diagnosis using multivariate logistic regression.

Results

A total of 4,137 patients with GBM were included, with a median overall survival of 4 months. Sixty‐one percent of patients underwent resection at diagnosis; 65% received RT and 10% received chemotherapy within 3 months of diagnosis. In a multivariate regression analysis, age was the most significant predictor of resection, RT, or chemotherapy. Black race (odds ratio [OR], 0.64; p = 0.008) was associated with lower rates of surgical resection. Factors associated with decreased likelihood of receiving RT included unmarried marital status (OR, 0.64; p < 0.0001) and more comorbidities (OR, 0.55; p < 0.0001). Factors associated with decreased likelihood of receiving chemotherapy included unmarried marital status (OR, 0.59; p = 0.0002) and more comorbidities (OR, 0.56; p = 0.02).

Interpretation

Survival of elderly GBM patients was poor in this population‐based study. Age, marital status, and comorbidities influenced the probability of receiving RT or chemotherapy in this cohort. Ann Neurol 2008;64:628–634