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Patterns of antibodies against latent and lytic antigens of human herpesvirus 8 in an endemic population and patients with Kaposi's sarcoma in Mozambique

✍ Scribed by Adele Caterino-de-Araujo; Mariana Cavalheiro Magri; Rolanda Carmen Rafael Manuel

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
132 KB
Volume
82
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The patterns of antibodies against latent and lytic antigens of human herpesvirus 8 (HHV‐8) were assessed using immunofluorescence assays of samples from 155 persons seropositive for HHV‐8 seen at public health centers and 24 patients with Kaposi's sarcoma (KS) from Mozambique. Of the 155 persons without KS, 48 (31%) had antibodies against latent antigens only, 29 (18.7%) had antibodies against lytic antigens only, and 78 (50.3%) had antibodies against both types of antigen. The HHV‐8 antibody titer tended to increase with age until age 40, after which it began to decrease. High titers of antibodies against latent and lytic antigens of HHV‐8 were detected mostly in persons co‐infected with HIV, and these increased titers could have a predictive value. All patients with KS except four patients who were seronegative for HHV‐8 had elevated titers of HHV‐8 antibodies, predominantly against latent antigens. The data suggest the potential for an increase in the development of KS in this endemic area for HHV‐8. J. Med. Virol. 82:1576–1581, 2010. © 2010 Wiley‐Liss, Inc.

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