Pattern of presenilin-1 expression during retinoic acid differentiation of SH-SY5Y neuroblastoma cells to a neuronal phenotype
โ Scribed by Flood, Fiona; Wiehager, Birgitta; Johnston, Janet; Sundstrom, Erik; Cowburn, Richard F.
- Book ID
- 122476310
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 164 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0197-4580
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## Abstract Presenilin 1 interacts with ฮฒโcatenin, an essential component of the Wnt signaling pathway. To elucidate the role of presenilin 1โฮฒโcatenin interaction in neuronal differentiation, we established SHโSY5Y cells stably expressing wildโtype presenilin 1, P117L mutant presenilin 1, which is
## Abstract To investigate the alteration of nuclear matrix proteins (NMPs) during the differentiation of neuroblastoma SKโNโSH cells induced by retinoic acid (RA), differentiation markers were detected by immunocytochemistry and NMPs were selectively extracted and subjected to twoโdimensional gel