Patients younger than 40 years with gastric carcinoma : Helicobacter pylori genotype and associated gastritis phenotype
✍ Scribed by Massimo Rugge; Graziella Busatto; Mauro Cassaro; Yih-Horng Shiao; Valentina Russo; Gioacchino Leandro; Claudio Avellini; Alfredo Fabiano; Angelo Sidoni; Antonello Covacci
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 91 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
In the general population, Helicobacter pylori (H. pylori), particularly the cagA positive strain, has been associated with intestinal-type gastric carcinoma. Gastric carcinomas are rarely observed in patients age Յ40 years.
Host-related factors have been thought to be more important than environmental agents in these early-onset cancers. The aim of this study was to ascertain the possible role of H. pylori infection and that of cagA positive strains in the development of gastric carcinoma in these young patients.