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Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

✍ Scribed by van den Bogaard, Bas; Holleboom, Adriaan G.; Duivenvoorden, Raphaël; Hutten, Barbara A.; Kastelein, John J.P.; Hovingh, G. Kees; Kuivenhoven, Jan Albert; Stroes, Erik S.G.; van den Born, Bert-Jan H.

Book ID
115544958
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
258 KB
Volume
225
Category
Article
ISSN
0021-9150

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High prevalence of mutations in LCAT in
High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in the Netherlands: Identification and characterization of eight novel mutations
✍ Adriaan G. Holleboom; Jan A. Kuivenhoven; Frank Peelman; Alinda W. Schimmel; Jor 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

Lecithin:cholesterol acyltransferase (LCAT) is crucial to the maturation of high-density lipoprotein (HDL). Homozygosity for LCAT mutations underlies rare disorders characterized by HDL-cholesterol (HDL-c) deficiency while heterozygotes have half normal HDL-c levels. We studied the prevalence of LCA