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Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

✍ Scribed by Andrzej Rochowski; Susan B. Olson; Todd A. Alonzo; Robert B. Gerbing; Beverly J. Lange; Blanche P. Alter


Book ID
112168170
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
64 KB
Volume
59
Category
Article
ISSN
1545-5009

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## Abstract Rearrangements of chromosome band 3q26.2 lead to overexpression of the __EVI1__ gene and are associated with a poor prognosis in myeloid malignancies. __EVI1__ is also overexpressed in some cases without 3q26 rearrangements. To uncover its prognostic significance in this patient group,