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Patient Transplant Survival Not Influenced by Type of Liver Graft

โœ Scribed by James D. Perkins


Book ID
102472038
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
79 KB
Volume
14
Category
Article
ISSN
1527-6465

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โœฆ Synopsis


Background. We studied patient and graft survival rates in adult liver transplant recipients, analyzing outcomes based on donor source (deceased donor [DD] vs. living donor [LD]) and graft type (whole liver vs. partial liver). Methods. A retrospective database analysis of all adult liver transplants performed at our center over a 7-year period of time. Results. Between 1999 and 2005, 384 liver transplants were performed in adult recipients, either as a whole liver from a deceased donor (DD-WL, nฯญ284), split liver from a DD (DD-SL, nฯญ31), or a partial transplant from a living donor (LD, nฯญ69). DD-SL transplants were performed with a full right or left lobe graft, while LD transplants used the right lobe. Demographic differences in the three groups were most noticeable for lower model for end-stage liver disease scores in LD recipients (Pฯฝ0.001) and younger donor age in DD-SL recipients (Pฯฝ0.001). Superior graft survival results were seen in LD recipients versus either DD-WL recipients or DD-SL recipients (Pฯญ0.02 and Pฯญ0.05, respectively). Multivariate analysis showed hepatitis C (HRฯญ1.53, Pฯญ0.05) and hepatocellular carcinoma (HRฯญ1.74, Pฯญ0.03) to be significant risk factors for patient survival. Hepatitis C (HRฯญ1.61, Pฯญ0.03) and donor age more than 50 (HRฯญ1.64, Pฯญ0.04) were significant risk factors for graft survival. However, neither graft type nor donor source were significant independent risk factors for patient or graft survival. Conclusions. Our data suggests that the status of the recipient is probably a more important determinant of outcome than graft type or donor source.


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