✦ LIBER ✦

Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis

✍ Scribed by A. Rashid Cheema; Evan M. Hersh

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 345 KB
Volume: 28
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(1971)28:4<851::aid-cncr2820280408>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

To study the relationship between chemotherapy immunocompetence and prognosis, in vitro lymphocyte blastogenic responses were studied serially, in 40 patients, receiving intensive chemotherapy for metastatic solid tumors. Suppression of lymphocyte blastogenic responses to phytohemagglutinin and streptolysin " 0 was similar in all patients a t the end of chemotherapy a n d was highly significant (PHA: P < 0.01, SLO: P < 0.02). Recovery of such responses occurred with significant overshoot above the pretreatment levels (P < 0.01)

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