Decitabine improves patient outcomes in
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Hagop Kantarjian; Jean-Pierre J. Issa; Craig S. Rosenfeld; John M. Bennett; Mahe
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Article
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2006
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John Wiley and Sons
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English
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## Abstract ## BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.