“Patient-Like” nude mouse metastatic model of advanced human pleural cancer

✍ Scribed by Philippe Astoul; Henri G. Colt; Xiaoen Wang; Christian Boutain; Dr. Rober M. Hoffman

• Book ID: 102877703
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 615 KB
• Volume: 56
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.240560104

✦ Synopsis

Pleural cancer in humans is a frequently occuring tumor. Recently, clinical trials have suggested that chemotherapy and immunotherapy administered intrapleurally may elicit responses in early-stage diseases. However, at radiological and pleural endoscopic evaluation, most of the patients are found to have a visceral pleural involvement that is generally refractory to therapy and leads to a poor prognosis. The goal of this study was to construct a nude mouse model of human parietal-and visceral-pleural cancer that could reflect the clinical picture for this disease. The model could then be useful for drug discovery for pleural cancer. A well-differentiated human lung adenocarcinoma was used as intact tissue for implantation. Ten mice underwent parietal-pleural implantation and ten mice visceral-pleural implantation via a novel thoracotomy procedure we have developed. Symptoms of tumor growth were determined from