## Abstract Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3–11 were treated in vit
Pathways to photoreceptor cell death in inherited retinal degenerations
✍ Scribed by Eric A. Pierce
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 249 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Retinitis pigmentosa (RP) is a heterogeneous group of diseases in which one of a wide variety of mutations selectively causes rod photoreceptor cell death. After rods die, cone photoreceptors gradually die resulting in blindness. Antioxidants reduce cone cell death in __rd1__/__rd1__ mi
## Abstract The phosphoinositide‐3‐kinase (PI3K)/protein kinase B (PKB)/Bad signal transduction pathway is engaged in the control of apoptosis in many different cell types, particularly through phosphorylation of the Bcl‐2 family protein Bad. We examined the involvement of this pathway in the contr
## Abstract Although the photoreceptors cell death is the main cause of some retinopathies diseases, the mechanisms involved in this process are poorly understood. The neuroprotective effects of interleukin‐4 (IL‐4) have been shown in several tissues, including retina. We demonstrate that treatment
## Abstract Glial cell line‐derived neurotrophic factor (GDNF) enhances the survival of a variety of neurons, including photoreceptors (PR) in the retina. In contrast to most other GDNF receptive neurons, GDNF does, however, not exert its neuroprotective activity directly on PR neurons but transmit