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Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations

✍ Scribed by Sonia Franco; Frederick W. Alt; John P. Manis

Book ID
116410595
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
213 KB
Volume
5
Category
Article
ISSN
1568-7864

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The frequency of acute myeloid leukemia (AML) with balanced chromosomal translocations arising after anticancer therapy with DNA-damaging agents such as DNA topoisomerase II inhibitors has increased over the last two decades. However, factors that predispose to these therapy-related disorders are st