Pathways of Pyrimidine Salvage inStreptomyces
✍ Scribed by Lee E. Hughes; Debrah A. Beck; Gerard A. O’Donovan
- Book ID
- 105996079
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 79 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0343-8651
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📜 SIMILAR VOLUMES
In Saccharomyces cerevisiae, the protein encoded by the FUR1 gene is absolutely required for the expression of uracil phosphoribosyl transferase activity. The occurrence of semi-dominant mutations for 5-fluorouracil-(5FU)-resistance at this locus led us to clone and sequence the semi-dominant fur1-5
## Abstract In cultured fibroblasts, a mutation resulting in deficiency of a pyrimidine salvage enzyme leads to excretion of related pyrimidines. For example, absence of thymidine kinase led to loss of thymidine and deoxyuridine, and absence of deoxycytidine kinase to loss of deoxyuridine. Both wil