Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
โ Scribed by Sean D. McAllister; Ryuichi Murase; Rigel T. Christian; Darryl Lau; Anne J. Zielinski; Juanita Allison; Carolina Almanza; Arash Pakdel; Jasmine Lee; Chandani Limbad; Yong Liu; Robert J. Debs; Dan H. Moore; Pierre-Yves Desprez
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 426 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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## Abstract Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. Th
Breast cancers frequently over-express a number of growth factor receptors. In addition, elevated src family kinase activity is present in a percentage of these neoplasms and has been implicated in signal transduction in these cells. Therefore, inhibiting tyrosine kinase activity is a potential appr