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Pathways mediating abnormal intracortical inhibition in Parkinson's disease

✍ Scribed by Colum D. MacKinnon; Emily A. Gilley; Annette Weis-McNulty; Tanya Simuni

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
127 KB
Volume
58
Category
Article
ISSN
0364-5134

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To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. As markers