Pathways leading to cell death in T cells

✍ Scribed by Brian Wong; Yongwon Choi

• Book ID: 104358707
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 592 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80082-9

✦ Synopsis

Antigen-induced apoptosis of T cells is a highly regulated process which plays a key role in the elimination of self-reactive T cells and, thus, in the prevention of autoimmunity. It has recently become apparent that members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily regulate antigen-induced T-cell death. Studies characterizing genes which control TNF/TNFR superfamily expression and how TNF/TNFR signal transducers activate cell death machinery, such as caspases, have begun to reveal the molecular control of antigen-induced T-cell death.