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Pathophysiology of metabolic acidosis: effect of low pH on the hepatic uptake of lactate, pyruvate and alanine

โœ Scribed by L. Sestoft; P. D. Bartels; M. Folke

Book ID
119853630
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
477 KB
Volume
2
Category
Article
ISSN
0144-5979

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Treatment of lactic acidosis: effects of
Treatment of lactic acidosis: effects of dichloroacetate on lactate and pyruvate levels in the cerebrospinal fluid
โœ I. Okabe; H. Kodama; H. Shimoizumi; S. Kamoshita; S. Miyabayashi ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 89 KB

Sir: Dichloroacetate (DCA, 15-20 mg/kg per day) was given orally twice daily to a 12-mouth-old boy with congenital lactic acidosis [1,3]. The clinical and laboratory findings were compatible with Leigh syndrome [2]. Enzyme activities associated with lactate metabolism were normal in his fibroblasts