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Pathophysiological study of axonal degeneration in the gracile axonal dystrophy mutant mouse

โœ Scribed by Suh, Jun-Gyo; Tanaka, Kohichi; Yorifuji, Hiroshi; Wada, Keiji


Book ID
122435046
Publisher
Elsevier Science
Year
1994
Weight
114 KB
Volume
19
Category
Article
ISSN
0921-8696

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Calpains are calcium-activated cysteine proteases that are involved in cellular degradation in models of neurodegeneration. Calpains are the effectors of cytoskeletal disruption during axonal degeneration, a pathological feature of many neurological disorders. The WLD S mouse mutant is resistant to