Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury
✍ Scribed by Marisol Mirabelli-Badenier; Vincent Braunersreuther; Sébastien Lenglet; Katia Galan; Edvige Veneselli; Giorgio L. Viviani; François Mach; Fabrizio Montecucco
- Book ID
- 114727600
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 107 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0014-2972
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Despite dramatic improvements in the management of traumatic brain injury (TBI), to date there is no effective treatment available to patients, and morbidity and mortality remain high. The damage to the brain occurs in two phases, the initial primary phase being the injury itself, which is irreversi
## Abstract Tumor necrosis factor‐α (TNF‐α) is one of the mediators dramatically increased after traumatic brain injury that leads to the activation, proliferation, and hypertrophy of mononuclear, phagocytic cells and gliosis. Eventually, TNF‐α can induce both apoptosis and necrosis via intracellul