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Pathophysiological and therapeutic implications of receptor regulation

✍ Scribed by M.D. Hollenberg


Book ID
119111608
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
456 KB
Volume
6
Category
Article
ISSN
0165-6147

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In end-stage heart failure the expression of different myocardial regulatory proteins involved in the beta-adrenergic cAMP signalling pathway is altered. The downregulation of beta 1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding