Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm-iddmrat, a new model of spontaneous insulin-dependent diabetes mellitus
✍ Scribed by Anne Jörns; Birgit Kubat; Markus Tiedge; Dirk Wedekind; Hans-Jürgen Hedrich; Günter Klöppel; Sigurd Lenzen
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 519 KB
- Volume
- 444
- Category
- Article
- ISSN
- 1432-2307
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## Abstract ## Objective The contribution of innate immunity responsible for beta‐cell destruction in fulminant type 1 diabetes (FT1D) and slowly progressive insulin‐dependent diabetes mellitus (SPIDDM) is unclear. ## Research Design and Methods Islet‐cell expression of Toll‐like receptors (TLRs
To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibo