Pathology of hepatocellular carcinoma

✍ Scribed by Dr. Francesco Callea; Maurizio Favret; Carla Marino; Massimo Brisigotti

• Book ID: 102440833
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 218 KB
• Volume: 53
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930530544

✦ Synopsis

This study provides a guideline to a dynamic approach toward the diagnosis of hepatocellular carcinoma (HCC). Bile production, fibrinogen synthesis, Mallory body, fibrinogen ground-glass and abnormal glycogen bodies as a reflection of "clone" selection, and hepatitis B virus (HBV) antigen expression in tumor cells can be considered as markers for the morphological diagnosis of HCC.

The demonstration in tumor cells of these diagnostic features requires a careful screening of routinely stained preparations in search of suggestive, characteristic, specific, or pathognomonic features further supplemented by ancillary techniques, such as histochemistry , immunocytochemistry, and electron microscopy.