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Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities

✍ Scribed by De Angelis, E.


Book ID
111746114
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
417 KB
Volume
18
Category
Article
ISSN
0261-4189

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## Abstract The neural adhesion molecule P0, the most abundant glycoprotein in peripheral myelin of mammals, is a member of the immunoglobulin superfamily and expresses the L2/HNK‐1 and L3 oligosaccharides at a single N‐glycosylation site. It acts in both homophilic and heterophilic binding mechani