Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities
β Scribed by De Angelis, E.
- Book ID
- 111746114
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 417 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0261-4189
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Mutations in L1CAM, the gene encoding the transmembrane multifunctional neuronal adhesion molecule L1, are associated with neurodevelopmental disorders including X-linked hydrocephalus and mental retardation. Some amino acid substitutions in various extracellular domains of L1 are known to affect po
## Abstract The neural adhesion molecule P0, the most abundant glycoprotein in peripheral myelin of mammals, is a member of the immunoglobulin superfamily and expresses the L2/HNKβ1 and L3 oligosaccharides at a single Nβglycosylation site. It acts in both homophilic and heterophilic binding mechani