Numerous pathologic factors have heen identified as important in predicting outcome for women with endometrial adenocarcinoma. However, most patients have a mixture of good and bad factors. For these women, the prognosis is uncertain, and it is often unclear whether postoperative therapy is indicated.
METHODS. llsing univariate and multivariate analysis, we investigated the pathologic factors commonly reported to he of prognostic significance, using data from 819 patients with clinical Stages I and I1 endometrial adenocarcinorna from a Gynecologic Oncology Group study. Since the clinical stage frequently underestimated the surgical stage, models that designate the relative risk associated wirh each of the variables were created for both clinical and surgical Stage 1 and I1 patients.
RESULTS.
We confirmed the importance of age, depth of myometrial invasion, and to a lesser degree, histologic grade, and cell type, as independent prognostic variables.
CONCLUSIONS.
The relative risk of death can he determined using a simple multiplicative calculation, and the absolute risk can he estimated by inspection of the accompanying figures. These data can be used to provide patients with prognostic information and to help determine the need for postoperative adjuvant therapy.