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Pathologic concentrations of ammonium ions block l-glutamate uptake

✍ Scribed by E.Edward Mena; Carl W. Cotman


Book ID
115898001
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
271 KB
Volume
89
Category
Article
ISSN
0014-4886

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## Abstract An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have demonstrated previously that exposure of cultured cerebellar granule neurons to L‐__trans__‐pyrrolidine‐2,4‐dicarboxylate (PDC), a glutamate uptake inhibitor, i