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Pathogenetic significance of anti-lymphocyte autoantibodies in systemic lupus erythematosus

✍ Scribed by John B. Winfield; Toshihide Mimura


Book ID
118375430
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
529 KB
Volume
63
Category
Article
ISSN
1090-2341

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Significance of anti-lymphocyte antibodi
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Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.