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Pathogenesis of pterygium: role of Eph receptors and ligand ephrins

โœ Scribed by Garg, Prashant


Book ID
120981336
Publisher
Canadian Ophthalmological Society
Year
2009
Tongue
English
Weight
68 KB
Volume
44
Category
Article
ISSN
0008-4182

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## Abstract Eph receptors and their ephrin ligands constitute the largest subfamily of receptor tyrosine kinases and are components of the cell signaling pathways involved during development. Eph and ephrin overexpression have been documented in a variety of human cancers including gastrointestinal

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## Background The tissue distributions and functions of Eph receptors and their ephrin ligands have been well studied, however less is known about their evolutionary history. We have undertaken a phylogenetic analysis of Eph receptors and ephrins from a number of invertebrate and vertebrate species