Pathogen recognition by innate receptors
โ Scribed by Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 307 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1341-321X
No coin nor oath required. For personal study only.
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During infection or tissue damage, the innate immune system detects and responds to nucleic acids released from pathogens or damaged host cells. Accumulating evidence has showed that specific sequences, modifications or structures of nucleic acids influence their immunomodulatory activities. Resulti
## Abstract PRR recognize conserved structures on pathogenic microbes and are important for the defense against invading microorganisms. However, accumulating evidence indicates that many pathogens have evolved mechanisms to avoid recognition by PRR. One type of PRR is the macrophage scavenger rece