Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas
β Scribed by Drexler, H G; Gignac, S M; von Wasielewski, R; Werner, M; Dirks, W G
- Book ID
- 110054653
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 748 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0887-6924
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Anaplastic large cell lymphoma (ALCL) comprises a group of non-Hodgkin lymphomas characterized by the expression of the CD30/Ki-1 antigen. A subset of ALCL is characterized by chromosomal translocations involving the anaplastic lymphoma kinase (ALK) gene on chromosome 2. While the most common transl
## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPMβALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel