Paternal transmission of fragile X syndrome
β Scribed by Zeesman, Susan ;Zwaigenbaum, Lonnie ;Whelan, Donald T. ;Hagerman, Randi J. ;Tassone, Flora ;Taylor, Sherryl A.M.
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 138 KB
- Volume
- 129A
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Fragile X syndrome, the most common genetic disorder associated with mental retardation is caused by an expansion of the unstable CGG repeat within the __FMR1__ gene. Although overgrowth is not the main hallmark of this condition, the fragile X syndrome is usually included in the differ
The much-quoted prevalence figure of 1:1,000 males for fragile X syndrome is an overestimate in a mixed ethnic population. A reexamination of the individuals from whom those data were derived using molecular diagnostic techniques demonstrates a more realistic figure of 1:4,000 males.