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Passive transfer of insulitis and lymphopenia in the BB rat

✍ Scribed by Phillippe Poussier; Azima F. Nakhooda; Anders A.F. Sima; Errol B. Marliss


Book ID
119471542
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
867 KB
Volume
32
Category
Article
ISSN
1532-8600

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BB rats develop autoimmune diabetes mellitus at a high frequency. A key factor in the development of the disease is an autosomal recessive mutation determining peripheral T cell lymphocytopenia. Previous studies have suggested that the lymphopenia could be caused by increased cell death. Here we dem