Autoantibody production following allogeneic stem-cell transplantation is common and is often ascribed to the immune dysregulation associated with graft-versus-host disease. Recent data suggests that donor-memory B cells can be reactivated on exposure to antigen and result in antibody production in
Passive transfer of contact hypersensitivity to rubber following allogeneic bone marrow transplantation
β Scribed by T.W. Lucke; J.L. Bong; D. Clark; J.A. Murphy
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 135 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0007-0963
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We investigated the adoptive transfer of immunity to herpes simplex virus (HSV) in 61 recipients of T-cell-depleted marrow allografts. Up to 3 months after bone marrow transplantation (BMT), high titres of HSV antibody (Ab) are passively acquired from blood products. This antibody has a half-life of
## Abstract Previous work by Grob et al. [__Lancet__ i:774, 1987] has demonstrated that allogeneic, Tβcellβdepleted bone marrow transplant recipients have a better prognosis for reactivated cytomegalovirus (CMV) infection if their donor is also immune. It was proposed that adoptively transferred hu
Recipients of allogeneic bone marrow transplantation are pancytopenic for several weeks and immunosuppressed for many months as a result of myeloablative therapy required to eliminate the basic disease and to prevent allograft rejection. After bone marrow transplantation, these patients remain profo