✦ LIBER ✦

Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: A case-control study

✍ Scribed by Manal M. Hassan; James L. Abbruzzese; Melissa L. Bondy; Robert A. Wolff; Jean-Nicolas Vauthey; Peter W. Pisters; Douglas B. Evans; Rabia Khan; Renato Lenzi; Li Jiao; Donghui Li

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 102 KB
Volume: 109
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.22724

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND.

The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear.

METHODS.

In this case‐control study, the authors collected information on passive smoking and the use of noncigarette tobacco products in 808 patients with pancreatic adenocarcinoma and 808 healthy controls by personal interview. Multivariable logistic regression was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (95% CI).

RESULTS.

The results confirmed the previously reported association between active smoking and increased risk for pancreatic cancer. The AOR was 1.7 (95% CI, 1.4–2.2) for regular smokers, 1.8 (95% CI, 1.4–2.4) for long‐term smokers, and 3.1 (95% CI, 2.2–4.3) for former smokers. Although passive smoking showed a nonsignificantly elevated risk for pancreatic cancer in the entire study population (AOR, 1.3; 95% CI, 0.9–1.7), the association was present among ever smokers (AOR, 1.7; 95% CI, 1.03–2.6) but was absent among never smokers (AOR, 1.1; 95% CI, 0.8–1.6). Neither intensity nor duration of passive smoking modified the risk of pancreatic cancer among never smokers. The use of chewing tobacco, snuff, and pipes showed no significant risk elevation for pancreatic cancer after controlling for the confounding effects of demographics and other known risk factors. The use of cigars in never smokers showed a borderline significant increase of risk for pancreatic cancer (AOR, 2.2; 95% CI, 1.0–4.7; P = .05).

CONCLUSIONS.

The current observations did not support a role for passive smoking or the use of noncigarette tobacco products in the etiology of pancreatic cancer. The association between cigar use and the risk of pancreatic cancer needs to be confirmed in other study populations. Cancer 2007. © 2007 American Cancer Society.

📜 SIMILAR VOLUMES

Passive smoking and the use of noncigare

Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer : A case-control study

✍ Gabriele Capurso; Holger Schunemann; Gianfranco Delle Fave 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 37 KB

W e read with interest the study by Hassan and colleagues 1 that evaluated a possible association between passive smoking and pancreatic cancer. The authors report that passive smoking is not a significant risk factor for pancreatic cancer, although it may increase the risk in smokers who are also e

Reply to passive smoking and the use of

Reply to passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer : A case-control study

✍ Donghui Li; Manal M. Hassan 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 37 KB 👁 1 views

Tobacco smoking and the risk of upper ae

Tobacco smoking and the risk of upper aero-digestive tract cancers: A reanalysis of case–control studies using spline models

✍ Jerry Polesel; Renato Talamini; Carlo La Vecchia; Fabio Levi; Luigi Barzan; Dieg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 182 KB 👁 1 views

## Abstract Although tobacco smoking has long been recognized as a major risk factor for cancer of the upper aero‐digestive tract (UADT, __i.e__., oral cavity, pharynx, larynx, and oesophagus), very few studies have provided estimates of the effect of very low tobacco consumption. Step‐functions ha

Risk modification by CYP1A1 and GSTM1 po

Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: A case-control study in Japanese nonsmoking women

✍ Chikako Kiyohara; Kenji Wakai; Haruo Mikami; Koichi Sido; Masahiko Ando; Yoshiyu 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB 👁 2 views

## Abstract Genetic backgrounds may modify the association of environmental tobacco smoke (ETS) with lung cancer risk. Polymorphisms of both the activating and detoxifying enzymes, cytochrome P4501A1 (CYP1A1) and glutathione‐S‐transferase M1 (GSTM1), may be important as genetic factors. We conducte

The association of cyclin D1 G870A and E

The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis

✍ Xiang-Lin Tan; Alexandra Nieters; Silke Kropp; Michael Hoffmeister; Hermann Bren 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 262 KB 👁 1 views

## Abstract Cyclin D1 (CCND1) and E‐cadherin (CDH1) have been shown to be important genes of the β‐catenin/LEF pathway that is involved in colorectal carcinogenesis. However, epidemiological studies on relationship between genetic variants of these two genes and colorectal cancer (CRC) have shown i

Both high and low levels of blood vitami

Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: A longitudinal, nested case-control study in the Nordic countries

✍ Pentti Tuohimaa; Leena Tenkanen; Merja Ahonen; Sonja Lumme; Egil Jellum; Göran H 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 81 KB 👁 2 views

## Abstract Vitamin D inhibits the development and growth of prostate cancer cells. Epidemiologic results on serum vitamin D levels and prostate cancer risk have, however, been inconsistent. We conducted a longitudinal nested case‐control study on Nordic men (Norway, Finland and Sweden) using serum