Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers

Contributions of saturable active secret

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells

✍ Shawn D. Flanagan; Lpori H. Takahashi; Xiaoli Liu; Leslie Z. Benet 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

Furosemide permeation across Caco-2 cells was investigated to determine if previously reported directional differences in transport rates are due to a saturable, energy dependent process. In addition, studies were carried out to determine the route of permeation for this drug. By comparing apical (A