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Parvovirus 4 in French in-patients: A study of hemodialysis and lung transplant cohorts

✍ Scribed by Mhammed Touinssi; Martine Reynaud-Gaubert; Carine Gomez; Pascal Thomas; Bertrand Dussol; Yvon Berland; Agnes Basire; Christophe Picard; Jean-François Cantaloube; Philippe de Micco; Philippe Biagini

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
84 KB
Volume
83
Category
Article
ISSN
0146-6615

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✦ Synopsis

The epidemiology and the clinical implication of human parvovirus 4 (PARV4) in human populations is still under evaluation. The distribution of PARV4 DNA was determined in cohorts of French hemodialysis and lung transplant patients. Plasma samples (n ¼ 289) were tested for PARV4 by real-time PCR assay (ORF2), and amplification products selected at random were sequenced. Analysis of available serological and biological markers was also undertaken. Fiftyseven samples out of 185 (30.8%) were positive for PARV4 DNA in the cohort of hemodialysis patients. A higher prevalence of the virus was identified in patients with markers of HBV infection. PARV4 was also identified in 14 out of 104 samples (13.5%) from lung transplant recipients, with no clear-cut association with available clinical markers. Point mutations located on the zone of real-time detection were identified for some amplification products. This study describes the detection of PARV4 in the blood of hemodialysis and lung transplanted patients with significant difference in prevalence in these two cohorts. Further studies will be needed in order to understand better both the potential implication in host health and the natural history of this virus.

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