Partition of circulating lead between serum and red cells is different for internal and external sources of lead

✍ Scribed by K. M. Cake; R. J. Bowins; C. Vaillancourt; C. L. Gordon; R. H. McNutt; R. Laporte; C. E. Webber; D. R. Chettle

• Book ID: 102650449
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 559 KB
• Volume: 29
• Category: Article
• ISSN: 0271-3586
• DOI: 10.1002/(sici)1097-0274(199605)29:5<440::aid-ajim2>3.0.co;2-q

✦ Synopsis

Serum lead, whole blood lend, and lead in both tibia and calcaneus were measured in each of 49 uctive leud workerA. Serum lead correluted more strongly with both in 1ivo bone lead measurements than did whole blood lead. The ratio of serum lead to whole blood lead 1,aried from 0.8% to 2.5% and showed a positive correlation with tibia, and an even stronger correlation with calcaneus lead. This implies that lead released ,from bone (endogenous exposure) results in a higher proportion of whole blood lead being in serum than is the case for exogenous exposure. This observation needs to be confirmed, and the relutionships amongst the parameters must be studied further, particularly in .former or retired lead workers. If c o n j h e d , since at least a portion of lead in serum is readily diffusible and thus toxicologically more immediately significant than lead bound to red cells, the heulth iinplications of endvgenous exposure may have to be reassessed. CI I996 WiIev-Liss. blc.