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Particle design of poorly water-soluble drug substances using supercritical fluid technologies

✍ Scribed by Takehiko Yasuji; Hirofumi Takeuchi; Yoshiaki Kawashima


Book ID
113418122
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
540 KB
Volume
60
Category
Article
ISSN
0169-409X

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A modified multifluid nozzle spray drier was used to prepare drug containing microparticles of a poorly water-soluble anti-malarial drug, artemisinin (ART) with the aim of improving its solubility. We investigated the spray drying of ART with maltodextrin (MD) via a full factorial experimental desig