## Abstract TAK‐778, a derivative of ipriflavone, has been shown to induce bone growth in in vitro and in vivo models. However, there are no studies evaluating by which mechanism TAK‐778 exerts its effect. Considering the evidences that its precursors act via classical estrogen‐receptor (ER)‐mediat
Participation of estrogen receptors in the enhancement of osteoblast differentiation by TAK-778
✍ Scribed by M´rcio Mateus Beloti; Larissa Sverzut Bellesini; Paulo Tambasco de Oliveira; Adalberto Luiz Rosa
- Book ID
- 106457774
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 398 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0300-8177
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## Abstract TAK‐778 has been shown to induce bone growth in in vitro and in vivo models. However, there are no studies evaluating the effect of TAK‐778 on human cells. Thus, the aim of this study was to investigate osteogenesis induced by TAK‐778 on human bone marrow cells. Cells were cultured in 2
## Abstract Although osteoblasts have been shown to respond to estrogens and express both isoforms of the estrogen receptor (ERα and ERβ), the role each isoform plays in osteoblast cell function and differentiation is unknown. The two ER isoforms are known to differentially regulate estrogen‐induci