Partial trisomy 22 resulting from rearrangements between chromosomes 11/22 and 16/22: a report of two cases
✍ Scribed by N Werding; H Holland; D Hueckel; UG Froster; HJ Häusler; W Kiess
- Book ID
- 114813806
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 323 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0803-5253
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We report on a 16-week-old male fetus with partial trisomy 16 and partial monosomy 22 resulting from 3:3 adjacent-2 segregation of a maternal balanced complex chromosome translocation involving chromosomes 5, 16, and 22. The karyotype of the 29-year-old p h e n o t y p i c a l l y n o r m a l m o t
T w o sibs, carriers of unbalanced products of the translocation t(15;21)(915;q22.l)pat, are described. The sister had Prader-Willi syndrome due to deletion 15 (pter > q15) and partial trisomy 21 (pter > q22.1); her brother had partial trisomy 15 (pter > q15) and partial monosomy 21 (pter > q22.1).