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Partial reversal of the antileukemic action of folic acid antagonists by nucleic acids

โœ Scribed by Howard E. Skipper; Martelia Bell; Juanita B. Chapman

Publisher
John Wiley and Sons
Year
1951
Tongue
English
Weight
241 KB
Volume
4
Category
Article
ISSN
0008-543X

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Studies on the antileukemic action of ce
Studies on the antileukemic action of certain compounds related to moieties of the 4-amino-pteroylglutamic acid (aminopterin) molecule
โœ Howard E. Skipper; Pradisth C. Edwards; Carl E. Bryan; Juanita B. Chapman; Marte ๐Ÿ“‚ Article ๐Ÿ“… 1950 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 258 KB ๐Ÿ‘ 1 views

first reported the palliative effects of 4-amino-pteroylglutamic acid in acute leukemia of children. Burchenal and associates2 observed that this compound and its "0-methyl analogue possessed the ability to prolong survival time of mice with a rather acute strain (Ak 4) of transplanted leukemia. The