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Partial Restoration of the Cardiac KCNQ1 Mutant A341V by the KCNE1 Auxiliary Subunit

✍ Scribed by Mikuni, Ikuomi; Bienengraeber, Martin; Torres, Carlos; Kwok, Wai-Meng


Book ID
119206802
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
49 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres