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Partial monosomy of distal 10q: Three new cases and a review

✍ Scribed by Waggoner, Darrel J.; Chow, Clara K.; Dowton, S. Bruce; Watson, Michael S.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 25 KB
Volume: 86
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990903)86:1<1::aid-ajmg1>3.0.co;2-a

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✦ Synopsis

We report on 3 patients with partial deletions of the long arm of chromosome 10-4 6 , X Y , d e l ( 1 0 ) ( q 2 6 . 2 ) , 4 6 , X X , d e l ( 1 0 ) (q25.3q26.3) or 46,XX,del(10)(q26.1), and 46,XX,del (10)(q26.1). They are compared with other known cases with interstitial or terminal deletions involving chromosome bands 10q25 or q26. Unique manifestations are identified, including scoliosis and a severe behavior disorder with attention deficit and hyperactivity in a 12-year-old boy as well as patchy alopecia in a 6-year-old patient.

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