Deficiency in DNA mismatch repair increa
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Aaron Mendez-Bermudez; Nicola J. Royle
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Article
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2011
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John Wiley and Sons
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English
β 339 KB
DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at