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Partial CD8+ T-cell depletion of allogeneic peripheral blood stem cell transplantation is insufficient to prevent graft-versus-host disease

✍ Scribed by Ho, V T; Kim, H T; Li, S; Hochberg, E P; Cutler, C; Lee, S J; Fisher, D C; Milford, E; Kao, G; Daley, H


Book ID
110014348
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
159 KB
Volume
34
Category
Article
ISSN
0007-1188

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Selective depletion of marrow-T cytotoxi
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In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedure has been associated with a high incidence of graft failure and leukemic relapse. In this