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Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors

✍ Scribed by Ron C. Hogg; Daniel Bertrand


Book ID
113488094
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
321 KB
Volume
73
Category
Article
ISSN
0006-2952

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Decamethonium is a partial agonist at th
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## Abstract The efficacy of decamethonium as an agonist at the nicotinic acetylcholine receptor has never been determined. Here, we demonstrate how patch clamp recording during rapid perfusion of agonists to outside‐out patches from BC3H‐1 cells can be used to provide an unambiguous estimate of the