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Part II: Bioavailability in Beagle Dogs of Nimodipine Solid Dispersions Prepared by Hot-Melt Extrusion

✍ Scribed by Zheng, Xin; Yang, Rui; Zhang, Yu; Wang, Zhijun; Tang, Xing; Zheng, Liangyuan


Book ID
124170565
Publisher
Informa plc
Year
2007
Tongue
English
Weight
274 KB
Volume
33
Category
Article
ISSN
0363-9045

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Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20Β°C, 40Β°C, 60Β°C) after milling. Conventional differential scanning calorimetr