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[Part 2: Biological Sciences] || Toward a Model for the Molecular Genetics of Carcinogenesis in Rats

โœ Scribed by Paul C. Kimball, M. Celeste Simon and Nirmal K. Mishra


Book ID
123670475
Publisher
National Academy of Sciences
Year
1980
Tongue
English
Weight
934 KB
Volume
77
Category
Article
ISSN
0027-8424

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Molecular genetic basis of renal carcino
โœ Okio Hino; Etsuko Kobayashi; Youko Hirayama; Toshiyuki Kobayashi; Yoshiaki Kubo; ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 382 KB

## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d