[Part 2: Biological Sciences] || Somatic Cell Genetic Analysis of Regulation of Expression of 3-hydroxy-3-methylglutaryl-coenzyme a Reductase
β Scribed by Michael Sinensky, Susan Armagast, Gail Mueller and Robert Torget
- Book ID
- 123674053
- Publisher
- National Academy of Sciences
- Year
- 1980
- Tongue
- English
- Weight
- 955 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/9609
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## Abstract Elevated 3βhydroxyβ3βmethylglutaryl coenzyme A (HMGβCoA) reductase expression supports synthesis of prenyl pyrophosphate intermediates required for tumor growth. In this study, the copy number of HMGβCoA reductase mRNA was determined in solid tumor and leukemic cell lines using competit
We have examined the amino terminal membrane anchoring domain of Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmg1p), a key enzyme of the isoprenoid biosynthetic pathway. Using both in vitro and in vivo approaches, we have analyzed a series of recombinant derivatives to iden