[Part 1: Physical Sciences] || Gas-Phase Pyrolytic Formation and Dimerization of Benzocyclobutenes: Synthesis of [24](1,2,4,5) Cyclophane

Reaction mechanisms in peptide synthesis

Reaction mechanisms in peptide synthesis. Part 1. Semiquantitative characteristics of the reactivity of 2-methyl-5(4H)-oxazolone with water and ammonia in the gas phase and weakly polar media

✍ Jerzy Ciarkowski; Francis M. F. Chen; N. Leo Benoiton 📂 Article 📅 1991 🏛 Springer Netherlands 🌐 English ⚖ 712 KB

2,4-Dialkyl-5(4H)-oxazolones are well-recognized intermediates in some aminolysis reactions in peptide synthesis. Using the MOPAC molecular orbital programs, detailed geometric and energetic characteristics of the elementary reaction pathways for the additions of water and ammonia to 2-methyl-5(4H)-